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KMID : 1007520230320030265
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Food Science and Biotechnology
2023 Volume.32 No. 3 p.265 ~ p.282
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Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer
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Qi-Zhang Li
Ze-Rong Zhou
Cui-Yu Hu
Xian-Bin Li
Yu-Zhou Chang
Yan Liu
Yu-Liang Wang
Xuan-Wei Zhou
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Abstract
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Proteins do not only serve as nutrients to fulfill the demand for food, but also are used as a source of bioactive proteins/polypeptides for regulating physical functions and promoting physical health. Female breast cancer has the highest incidence in the world and is a serious threat to women’s health. Bioactive proteins/polypeptides exert strong anti-tumor effects and exhibit inhibition of multiple breast cancer cells. This review discussed the suppressing effects of bioactive proteins/polypeptides on breast cancer in vitro and in vivo, and their mechanisms of migration and invasion inhibition, apoptosis induction, and cell cycle arrest. This may contribute to providing a basis for the development of bioactive proteins/polypeptides for the treatment of breast cancer.
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KEYWORD
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Bioactive proteins, Bioactive polypeptides, Breast cancer, Inhibition, Mechanisms
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